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|Melodical Muse Pretty Cure|
|Opening Song||Rising! Melodical Muse Pretty Cure!|
|Ending Song||Mirai Rhythm|
Omaru Hibiku (小丸響く?) / Cure Etude (キュアエチュード?) - The lead cure of the series. Hibiku is a new transfer student from Kyoto but is very shy and quiet, to the point of being classed as emotionless. Despite being a girl of a few words, Hibiku loves to sing and even writes her own music. Her Pretty Cure alter ego is Cure Etude (キュアエチュード?), the heart of musical blessings whose theme color is orange.
Kazahara Sora (風原そら?) / Cure Phrase (キュアフレーズ?) - An energetic and sporty girl in Hibiku's class who loves to play badminton and tennis, Sora tends to be late for class and is often in detention misbehaving. However, Sora has a courageous heart and is very popular. Her Pretty Cure alter ego is Cure Phrase (キュアフレーズ?), the heart of musical courage whose theme color is blue.
Kayano Miku (萱野未来?) / Cure Serenade (キュアセレナーデ?) - The student council vice president of the school, Miku is a very intelligent but stubborn girl who tends to be pushed away by fellow classmates for her antisocial behaviour. She can also be quite secretive and quiet when it comes to her true feelings. Her Pretty Cure alter ego is Cure Serenade (キュアセレナーデ?), the heart of musical trust whose theme color is purple.
Inoue Kanae (井上香苗?) / Cure Tone (キュアトーン?) / Princess Tempo (プリンセステンポ?) - The veteran Cure of the team, Kanae is from the Crescendo Skye as well as the princess of the kingdom. However, she, along with Mero, fled from the kingdom as her parents sadly got frozen in time after the attack. She is also very elegant and gentle with the people around her as a future queen. Her Pretty Cure alter ego is Cure Tone (キュアトーン?), the heart of musical tranquillity whose theme color is green.
Muse Commune (ミューズコミューン?) - The transformation item of the series. To activate the Communes' powers, each girl needs to shout "Pretty Cure, Muse Completion!" and each girl needs a Muse Shard of their respective color.